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(-)-U-50488 hydrochloride

CAS No. 114528-79-9

(-)-U-50488 hydrochloride( U50488 | U-50488 )

Catalog No. M10515 CAS No. 114528-79-9

The more active enantiomer of (±)-U-50488, a potent, selective kappa-opioid receptor agonist with no μ-opioid antagonist effects.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    (-)-U-50488 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    The more active enantiomer of (±)-U-50488, a potent, selective kappa-opioid receptor agonist with no μ-opioid antagonist effects.
  • Description
    The more active enantiomer of (±)-U-50488, a potent, selective kappa-opioid receptor agonist with no μ-opioid antagonist effects; shows analgesic, diuretic and antitussive effects, and reverses the memory impairment produced by anticholinergic drugs in vivo.Anxiety Discontinued.
  • In Vitro
    (-)-U-50488 hydrochloride (1 pM-100 nM; 7 days) exhibits a concentration-dependent inhibition of HIV-1 expression, the maximal inhibition at 10?13 M (approximately 73% suppression) in acutely infected blood monocyte-derived macrophages (MDM).(-)-U-50488 hydrochloride (10-13 M; 7-14 days) (10?13 M) markedly inhibits HIV-1 expression both at 7 and 14 days after infection, it has a sustained inhibitory effect on HIV-1 infection in MDM.
  • In Vivo
    (-)-U-50488 hydrochloride (intraperitoneal?injection?; 5mg/kg; 2 hrs before 4% paraformaldehyde (PFA)) acutely induced pMeCP2-S421 (phosphorylation of the methyl-DNA binding protein MeCP2 at Ser421) and Fos selectively in the nucleus accumbens (NAc) but does not alter MeCP2 levels in any brain region. Animal Model:C57BL/6J mice Dosage:5 mg/kg Administration:Intraperitoneal?injection; single dose; 2 hrs before 4% PFAResult:Induced pMeCP2-S421 in the brain acutely.
  • Synonyms
    U50488 | U-50488
  • Pathway
    Endocrinology/Hormones
  • Target
    Opioid Receptor
  • Recptor
    Opioid Receptor
  • Research Area
    Neurological Disease
  • Indication
    Anxiety

Chemical Information

  • CAS Number
    114528-79-9
  • Formula Weight
    405.79
  • Molecular Formula
    C19H26Cl2N2O.HCl
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?H2O : 50 mg/mL (123.22 mM)
  • SMILES
    CN(C1CCCCC1N2CCCC2)C(=O)CC3=CC(=C(C=C3)Cl)Cl.Cl
  • Chemical Name
    trans-(-)-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide hydrochloride

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Tao PL, et al. Eur J Pharmacol. 1994 May 2;256(3):281-6. 2. Suarez-Roca H, et al. J Pharmacol Exp Ther. 1993 Feb;264(2):648-53. 3. Su MT, et al. Br J Pharmacol. 1998 Feb;123(4):625-30. 4. Vonvoigtlander PF, et al. J Pharmacol Exp Ther. 1983 Jan;224(1):7-12.
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